Item 2.02    Results of Operations and Financial Condition.

On April 13, 2026, Spyre Therapeutics, Inc. (the "Company") announced that while the Company has not finalized its full financial results for the quarter ended March 31, 2026, the Company expects to report that it had approximately $741 million of cash, cash equivalents and marketable securities as of March 31, 2026. This amount includes $30 million of legacy asset disposition proceeds collected during the quarter ended March 31, 2026, of which approximately $23 million is expected to be paid to holders of the Company's contingent value rights during the second quarter of 2026.

These amounts are preliminary, have not been audited and are subject to completion of the Company's financial closing procedures. Neither the Company's independent registered public accounting firm nor any other publicly registered accounting firm has audited, reviewed or performed any procedures with respect to this preliminary information and, accordingly, no firm has expressed an opinion or any other form of assurance with respect thereto. Consequently, these amounts may differ materially from the amounts that will be reflected in the Company's unaudited consolidated balance sheet as of March 31, 2026.

The information in this Item 2.02 shall not be deemed to be "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Exchange Act or under the Securities Act of 1933, as amended, except as expressly provided by specific reference in such filing.

Item 8.01    Other Events.

Effective April 13, 2026, the Company suspended and terminated the prospectus (the "ATM Prospectus") relating to the sale of its common stock, $0.0001 par value per share (the "Common Stock") in an "at-the-market" offering pursuant to the terms of the Sales Agreement, dated, September 6, 2024, by and between the Company and TD Securities (USA) LLC (the "Sales Agreement"). As a result, the Company will not make any sales of its Common Stock pursuant to the Sales Agreement unless and until a new prospectus, prospectus supplement or registration statement is filed. Other than the termination of the ATM Prospectus, the Sales Agreement remains in full force and effect.