The Africa Clinical Research Network (ACRN) has launched its first clinical trial with Oracle in Africa, which commenced in February 2026. The PROgnostic Testing to Enhance Clinical Triage of Pre-eclampsia in Africa (PROTECT-Africa) trial aims to define, validate, and evaluate the clinical performance of placental biomarkers using innovative point-of-care platforms. The study will predict the absence or occurrence of severe pre-eclampsia-related maternal and fetal outcomes among African women with hypertensive disorders of pregnancy.