Under this initiative, MitoCareX intends to combine two complementary and independently validated capabilities: MitoCareX’s proprietary MITOLINE® algorithm platform and Boltz’s foundation models for predicting biomolecular structure and binding affinity and designing new molecules. MitoCareX believes this integrated approach can strengthen target-specific virtual screening campaigns for challenging transporter proteins and improve hit identification.

"MITOLINE® gives us target-specific structural insight, and Boltz adds additional AI-enabled capabilities that may help us identify differentiated starting points more efficiently", said David Palach, Chief Executive Officer of Nexentis Technologies Inc. "This approach is intended to expand our hit discovery efforts across selected transporter targets while preserving MitoCareX’s focus on building proprietary small-molecule programs."

Using MITOLINE®, MitoCareX previously identified initial hit molecules against a selected SLC25 target and has since advanced this program through systematic medicinal chemistry optimization, culminating in the generation of an optimized hit molecule with substantially improved pharmaceutical properties - as announced in May 2026.

The initial phase of the project with Boltz is expected to focus on a selected set of SLC protein targets and virtual screening campaigns designed to identify differentiated small-molecule starting points. Subject to the results of this initial phase, the companies may expand the scope of this initiative to additional targets within MitoCareX’s broader discovery activities. MitoCareX will retain full control over its discovery programs and any small-molecule candidates it advances using this combined approach.

Boltz describes Boltz Lab as a hosted platform that combines biomolecular foundation models, managed compute, and scientist-oriented workflows, and has publicly highlighted the deployment of its models with industry partners, including a strategic collaborations with Pfizer and Takeda. BoltzMol-1, the company’s small-molecule generative pipeline is designed to model complex structures and binding affinities and support in silico screening and design of small-molecule for drug discovery programs.

MitoCareX is focused on developing novel therapies for hard-to-treat cancers and inflammatory metabolic diseases. The Company believes that combining proprietary biological and structural insight with advanced AI tools may support a differentiated discovery strategy for novel transporter-focused therapeutics.