Ensysce Biosciences, Inc. (NASDAQ:ENSC) ("Ensysce" or the "Company"), a clinical-stage pharmaceutical company pioneering next-generation pain and central nervous system therapeutics engineered to minimize abuse and overdose risk, today announced initiation of the final stage of the PF614-MPAR-102 clinical study. The study is evaluating its novel MPAR® (Multi-Pill Abuse Resistance) overdose-protection technology.

Rather than relying on traditional abuse‑deterrent technologies, PF614‑MPAR is engineered to provide active protection against oral overdose, addressing one of the most persistent risks in opioid therapy. Its proprietary chemical‑control mechanism delivers therapeutic opioid exposure during prescribed use while automatically restricting additional release when excessive doses are taken. This built‑in "safety switch" establishes a new therapeutic paradigm: opioids designed not only for efficacy, but for controlled exposure under misuse conditions.