As announced, Jaguar received an upfront payment of $16M of non-dilutive capital in January 2026 upon entering U.S. license agreement with Future Pak for Mytesi® and Canalevia®-CA1 - Jaguar's two commercialized crofelemer drugs - an agreement that is fully aligned with company's strategy to concentrate crofelemer development efforts on human rare-disease intestinal failure (IF) indications

Presentation at ESPGHAN 2026 described additional groundbreaking results of evaluation of crofelemer as adjunctive oral therapy for the treatment of pediatric IF, which demonstrate reduction of parenteral support normalized to body weight of up to 48% in patient with the ultrarare microvillus inclusion disease (MVID)

SAN FRANCISCO, CA / ACCESS Newswire / August 5, 2026 / Jaguar Health, Inc. (NASDAQ:JAGX) ("Jaguar") today announced that its wholly-owned subsidiary Napo Pharmaceuticals, Inc. (collectively, with Jaguar Health, Inc., "Jaguar") has satisfied the conditions required to receive payment of the non-dilutive $2 million holdback amount from Future Pak, LLC ("Future Pak") related to the U.S. commercial licensing agreement Jaguar entered in January 2026 with a Future Pak affiliate. As announced, Jaguar was provided with a partial upfront fee of $16 million of non-dilutive capital upon closing of the agreement. Per the terms of the agreement, the additional $2 million portion of the upfront fee ("the Holdback Amount") is due to Jaguar upon Jaguar's completion of specified post-closing conditions, which the company has met.

Upon the closing of the agreement, Future Pak became the exclusive marketer for Mytesi (crofelemer), Jaguar's FDA-approved novel prescription drug for the symptomatic relief of noninfectious diarrhea in adult patients with HIV/AIDS on antiretroviral therapy, and Canalevia-CA1, Jaguar's crofelemer prescription drug for the treatment of chemotherapy-induced diarrhea in dogs. As announced in March 2026, Jaguar received an additional $3 million payment from Future Pak related to the agreement and, per the terms of the agreement, Jaguar has the remaining opportunity to receive up to $17 million in additional milestone payments and other future payments.