TuHURA Biosciences, Inc. (NASDAQ:HURA) (“TuHURA” or the “Company”), a Phase 3 immuno-oncology company developing novel therapeutics to overcome resistance to cancer immunotherapy, today announced that the United States Patent and Trademark Office has issued U.S. Patent No. 12,734,168 entitled, “Delta Opioid Receptor Antagonists Reprogram Immunosuppresive Microenvironment to Boost Immunotherapy.” The patent is directed to, among other things, administration of DOR antagonists to subjects having cancer associated with DOR expressing Myeloid Derived Suppressor Cells (MDSCs).  It is further directed to uses of a variety of DOR antagonist combination therapies in treating, inhibiting, reducing, ameliorating, and/or preventing cancer and/or metastasis.