- New biopsy data demonstrate thatPBGENE-HBV directly eliminated cccDNA through its primary mechanism leading to a 1-log (10-fold) reduction in cccDNA-derived transcripts -

- In the <1% of cccDNA remaining, PBGENE-HBV indels permanently inactivated viral replication by knocking out polymerase function -

- pgRNA established as the biomarker to directly reflect cccDNA elimination by PBGENE-HBV -

- New clinical data demonstrate that PGENE-HBV achieved pgRNA loss in 100% of patients with detectable pgRNA at baseline -

- PBGENE-HBV has a clear therapeutic window with a well-characterized and manageable safety profile across multiple dosing cohorts -

- Investor webcast with investigators and key opinion leaders today at 8:00 AM EDT -