• Late-breaking Phase II data highlight enicepatide's (CT-388) efficacy and safety, reinforcing its potential to deliver best-in-class weight loss across a broad population of people living with overweight or obesity
  • Late-breaking data from the Phase II ZUPREME-1 trial showcase petrelintide's efficacy, safety, and compelling tolerability profile, which has the potential to redefine the weight management experience for people living with overweight or obesity
  • A Phase II multi-arm trial evaluating enicepatide and petrelintide fixed-dose combinations will be initiated towards mid-2026 to develop a differentiated treatment option

Basel, 1 June 2026 - Roche ((SIX: RO, ROP, OTCQX:RHHBY) announced today that new data from its obesity portfolio will be presented at the 2026 Scientific Sessions of the American Diabetes Association® (ADA). The insights demonstrate significant progress in addressing a range of unmet needs for people living with obesity or overweight such as long-term treatment adherence, which could be supported by a favorable safety and tolerability profile.

"The data we will present at ADA highlight the growing strength of our obesity portfolio, exemplified by the robust efficacy and distinct tolerability profiles of enicepatide and petrelintide," said Levi Garraway, MD, PhD, Roche's Chief Medical Officer and Head of Global Product Development. "The clinical insights from these studies demonstrate how our portfolio may offer more tailored, individualised treatment options for people living with obesity."

The data presented on Roche's obesity assets include:

  • Enicepatide (CT-388): Late-breaking data from the Phase II (CT388-103) study will highlight clinical weight loss outcomes from investigational enicepatide in people living with overweight/obesity. The dual GLP-1/GIP receptor agonist is also being investigated in an additional Phase II study (CT388-104) to evaluate its efficacy, safety and tolerability in participants who are living with obesity or are overweight and have type 2 diabetes (T2D). These data suggest that enicepatide could emerge as an important medicine in its own right and also a key backbone for potential combination therapies from Roche's cardiometabolic pipeline.
  • Petrelintide: Late-breaking data from the Phase II ZUPREME-1 trial highlight the efficacy and safety of petrelintide, an investigational human amylin analog being evaluated for weight management in people living with overweight and obesity. The ongoing Phase II petrelintide monotherapy trial, ZUPREME-2 is evaluating petrelintide versus placebo in people living with obesity or overweight and T2D. As monotherapy and in combination with enicepatide, petrelintide can become an important component of Roche's portfolio.

Roche continues to advance its weight management pipeline rapidly, moving both enicepatide and petrelintide into Phase III development while initiating a Phase II multi-arm combination trial in mid-2026.