The transaction meaningfully strengthens Edgewise's balance sheet, providing enhanced financial flexibility and sharpening the Company's strategic focus to accelerate and unlock the full potential of its cardiovascular pipeline. Following the closing of the transaction, Edgewise will become a cardiovascular focused company, with a pipeline comprising EDG-7500 for hypertrophic cardiomyopathy, EDG-15400 for HFpEF and EDG-003 for an undisclosed target.

Under the terms of the agreement, Servier will acquire all rights to sevasemten, including related intellectual property, know-how, key agreements, regulatory filings, and clinical data required to operate the muscular dystrophy business. All Edgewise employees who primarily support the muscular dystrophy business will receive a comparable offer at Servier to ensure continuity of development and future commercial execution. The transaction reflects Edgewise's strategic focus on advancing its cardiovascular portfolio, while positioning sevasemten with an acquirer who brings the global development, regulatory, and commercial capabilities required to fully realize sevasemten's potential for patients.

"Servier's focus on precision therapeutics and its dedication to rare neurological and neuromuscular diseases make them the ideal steward for the program," said Kevin Koch, Ph.D., President and Chief Executive Officer of Edgewise Therapeutics. "This transaction delivers immediate, significant value — including $1.55 billion upfront — while placing sevasemten with an acquirer that has the global scale, patient commitment, and commercial reach to maximize its potential for individuals living with Becker and Duchenne muscular dystrophy. Equally important, this transaction strengthens our balance sheet and provides financial flexibility to advance EDG-7500 and EDG-15400 through key value-inflection points."

"Edgewise is a pioneer in muscle disease biology with a proven track record of discovering and developing precision therapies for patients with serious neurological conditions," said Olivier Laureau, President of Servier. "The acquisition of sevasemten and Edgewise's muscular dystrophy business, including highly experienced talent across research, development, regulatory, and commercial functions, provides an immediate platform to expand our portfolio into Becker and Duchenne muscular dystrophy. In line with our 2030 ambition, this positions us as a major player in neuromuscular indications to serve more patients living with devastating rare diseases."

Advancing the Cardiovascular Pipeline

Separately, the Company reaffirmed that it plans to report 12-week data from Part D of the CIRRUS-HCM Phase 2 trial of EDG-7500 in the second quarter of 2026. The 12-week Part D data, which will include safety, echocardiographic, biomarker, and patient-reported outcome assessments across both oHCM and nHCM, are expected to inform the Phase 3 design, with initiation targeted for the fourth quarter of 2026.   In parallel, Edgewise remains on track to initiate a Phase 2 trial of EDG-15400 in heart failure with preserved ejection fraction (HFpEF), further advancing the Company's cardiovascular pipeline. Additionally, the Company believes the upfront proceeds from this transaction, combined with its existing cash position, will fully fund EDG-7500 development through potential approval and provide the financial strength to further build and expand its cardiovascular pipeline.