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BAKER BROS. ADVISORS LP
Period ended Jun 30, 2026 · Latest filing Aug 14, 2026
These quarterly holdings are delayed and may not include all assets or short positions.
Values are from the reporting date, not current prices or purchase costs.
The same security may appear in multiple rows.
Source: SEC
Reported portfolio value
Quarter-end reported holdings; not current value or investment performance.
View reported values
- Jun 30, 2026: $19,955,238,553
More quarters will appear as history becomes available.
Top holdings
Top 10 at Jun 30, 2026. Matching entries are combined; security classes and options remain separate. Shares exclude principal amounts; option shares reflect the reported underlying amount.
View top holdings values
- Incyte Corporation · COM · 45337C102 · shares: $3,487,217,729
- BeOne Medicines Ltd. · SPONSORED ADS · 07725L102 · shares: $2,508,182,548
- Revolution Medicines, Inc. · COM · 76155X100 · shares: $2,143,111,899
- Madrigal Pharmaceuticals, Inc. · COM · 558868105 · shares: $1,150,754,190
- ACADIA Pharmaceuticals Inc. · COM · 004225108 · shares: $1,085,696,471
- Kymera Therapeutics, Inc. · COM · 501575104 · shares: $992,725,940
- Insmed Incorporated · COM PAR $.01 · 457669307 · shares: $937,841,355
- Celcuity Inc. · COM · 15102K100 · shares: $828,150,159
- Kodiak Sciences Inc. · COM · 50015M109 · shares: $776,051,487
- Rhythm Pharmaceuticals, Inc. · COM · 76243J105 · shares: $622,265,747
Reported holdings
84 reported entries| Issuer | Class | CUSIP | Type | Shares / principal | Reported value (USD) |
|---|---|---|---|---|---|
| Incyte Corporation | COM | 45337C102 | — | 30,762,330 shares | $3,487,217,729 |
| BeOne Medicines Ltd. | SPONSORED ADS | 07725L102 | — | 8,801,567 shares | $2,508,182,548 |
| Revolution Medicines, Inc. | COM | 76155X100 | — | 11,443,357 shares | $2,143,111,899 |
| Madrigal Pharmaceuticals, Inc. | COM | 558868105 | — | 2,143,131 shares | $1,150,754,190 |
| ACADIA Pharmaceuticals Inc. | COM | 004225108 | — | 42,912,904 shares | $1,085,696,471 |
| Kymera Therapeutics, Inc. | COM | 501575104 | — | 8,657,242 shares | $992,725,940 |
| Insmed Incorporated | COM PAR $.01 | 457669307 | — | 8,796,111 shares | $937,841,355 |
| Celcuity Inc. | COM | 15102K100 | — | 7,915,792 shares | $828,150,159 |
| Kodiak Sciences Inc. | COM | 50015M109 | — | 19,919,186 shares | $776,051,487 |
| Rhythm Pharmaceuticals, Inc. | COM | 76243J105 | — | 5,604,483 shares | $622,265,747 |
| Praxis Precision Medicines, Inc. | COM | 74006W207 | — | 1,753,198 shares | $586,953,158 |
| Alkermes plc | SHS | G01767105 | — | 10,012,267 shares | $524,592,729 |
| Summit Therapeutics Inc. | COM | 86627T108 | — | 32,786,348 shares | $477,697,090 |
| GRAIL, Inc. | COM | 384747101 | — | 4,028,614 shares | $275,033,478 |
| AbCellera Biologics Inc. | COM | 00288U106 | — | 33,012,138 shares | $259,145,283 |
| Immunovant, Inc. | COM | 45258J102 | — | 5,435,220 shares | $209,419,027 |
| IDEAYA Biosciences, Inc. | COM | 45166A102 | — | 5,010,030 shares | $186,723,818 |
| Kiniksa Pharmaceuticals International, plc | ORD SHS CL A | G52694109 | — | 2,834,643 shares | $181,275,420 |
| Roivant Sciences Ltd. | SHS | G76279101 | — | 4,716,831 shares | $166,928,649 |
| Arrowhead Pharmaceuticals, Inc. | COM | 04280A100 | — | 1,992,783 shares | $162,431,742 |
| Ionis Pharmaceuticals, Inc. | COM | 462222100 | — | 2,047,727 shares | $162,364,274 |
| Edgewise Therapeutics, Inc. | COM | 28036F105 | — | 3,701,719 shares | $150,400,843 |
| Replimune Group, Inc. | COM | 76029N106 | — | 11,045,336 shares | $122,271,870 |
| Nurix Therapeutics, Inc. | COM | 67080M103 | — | 4,658,556 shares | $113,016,569 |
| Stoke Therapeutics, Inc. | COM | 86150R107 | — | 3,336,697 shares | $109,176,726 |
| Monte Rosa Therapeutics, Inc. | COM | 61225M102 | — | 4,345,736 shares | $105,166,811 |
| Immatics N.V. | SHS | N44445109 | — | 9,508,565 shares | $96,321,763 |
| Denali Therapeutics Inc. | COM | 24823R105 | — | 3,734,336 shares | $96,047,122 |
| Crinetics Pharmaceuticals, Inc. | COM | 22663K107 | — | 2,351,465 shares | $87,991,820 |
| Dianthus Therapeutics, Inc. | COM | 252828108 | — | 852,164 shares | $83,068,947 |
| Structure Therapeutics Inc. | SPONSORED ADS | 86366E106 | — | 1,432,529 shares | $76,883,831 |
| Celcuity Inc. | Note 2.75% 8/1/2031 | 15102KAA8 | — | 30,750,000 principal | $69,158,687 |
| Rapport Therapeutics, Inc. | COM | 75383L102 | — | 1,547,090 shares | $64,467,240 |
| Alumis Inc. | COM | 022307102 | — | 2,012,500 shares | $56,631,750 |
| Prelude Therapeutics Inc. | COM | 74065P101 | — | 10,123,824 shares | $53,959,982 |
| Relay Therapeutics, Inc. | COM | 75943R102 | — | 2,826,783 shares | $52,889,110 |
| Mirum Pharmaceuticals, Inc. | COM | 604749101 | — | 445,975 shares | $52,210,293 |
| Bicycle Therapeutics plc | SPONSORED ADS | 088786108 | — | 10,885,357 shares | $46,153,914 |
| Enliven Therapeutics, Inc. | COM | 29337E102 | — | 905,191 shares | $45,938,443 |
| Celldex Therapeutics, Inc. | COM | 15117B202 | — | 1,182,611 shares | $44,004,955 |
| Viridian Therapeutics, Inc. | COM | 92790C104 | — | 2,383,025 shares | $43,776,169 |
| Design Therapeutics, Inc. | COM | 25056L103 | — | 2,678,430 shares | $38,756,882 |
| Entrada Therapeutics, Inc. | COM | 29384C108 | — | 5,072,730 shares | $37,335,293 |
| Faeth Therapeutics, Inc. | COM | 81728A207 | — | 1,286,411 shares | $32,160,275 |
| Aktis Oncology, Inc. | COM | 01021M104 | — | 996,351 shares | $32,112,393 |
| Neurogene Inc. | COM | 64135M105 | — | 991,691 shares | $31,188,682 |
| Jade Biosciences, Inc. | COM | 008064206 | — | 1,230,426 shares | $27,340,066 |
| Taysha Gene Therapies, Inc. | COM SHS | 877619106 | — | 4,004,756 shares | $27,272,388 |
| Arcus Biosciences, Inc. | COM | 03969F109 | — | 844,816 shares | $26,045,677 |
| Disc Medicine, Inc. | COM | 254604101 | — | 349,657 shares | $25,573,913 |
| Absci Corporation | COM | 00091E109 | — | 2,134,803 shares | $24,742,367 |
| Generate Biomedicines, Inc. | COM SHS | 370920100 | — | 1,423,602 shares | $24,016,166 |
| DBV Technologies S.A. | SPONSORED ADS | 23306J309 | — | 1,461,425 shares | $23,967,370 |
| Xenon Pharmaceuticals Inc. | COM | 98420N105 | — | 370,208 shares | $22,345,755 |
| Tectonic Therapeutic, Inc. | COM | 878972108 | — | 607,788 shares | $20,892,713 |
| Cerus Corporation | COM | 157085101 | — | 6,395,431 shares | $18,674,659 |
| CytomX Therapeutics, Inc. | COM | 23284F105 | — | 4,975,826 shares | $18,659,348 |
| Dyne Therapeutics, Inc. | COM | 26818M108 | — | 813,449 shares | $18,066,702 |
| Cytokinetics, Incorporated | COM | 23282W605 | — | 211,267 shares | $17,997,836 |
| Xencor, Inc. | COM | 98401F105 | — | 1,102,106 shares | $17,743,907 |
| Sionna Therapeutics, Inc. | COM | 829401108 | — | 400,000 shares | $17,596,000 |
| Intellia Therapeutics, Inc. | COM | 45826J105 | — | 930,232 shares | $15,739,525 |
| Parabilis Medicines, Inc. | COM | 698955101 | — | 500,000 shares | $13,685,000 |
| MapLight Therapeutics, Inc. | COM | 56565P103 | — | 364,705 shares | $13,071,027 |
| Avalyn Pharma Inc. | COM SHS | 05348Y105 | — | 350,000 shares | $11,522,000 |
| Evommune, Inc. | COM SHS | 30054Y107 | — | 847,390 shares | $11,261,813 |
| BioNTech SE | SPONSORED ADS | 09075V102 | — | 119,743 shares | $11,142,086 |
| Tango Therapeutics, Inc. | COM | 87583X109 | — | 333,333 shares | $10,419,990 |
| Avalo Therapeutics, Inc. | COM | 05338F306 | — | 550,000 shares | $10,164,000 |
| Sera Prognostics, Inc. | CLASS A COM | 81749D107 | — | 5,498,170 shares | $10,006,669 |
| Verastem, Inc. | COM | 92337C203 | — | 2,499,338 shares | $9,547,471 |
| Sagimet Biosciences Inc. | COM SER A | 786700104 | — | 952,996 shares | $7,366,659 |
| Eikon Therapeutics, Inc. | COM | 282564103 | — | 555,555 shares | $7,249,993 |
| LB Pharmaceuticals Inc. | COM SHS | 50180M108 | — | 200,000 shares | $6,491,000 |
| vTv Therapeutics, Inc. | CL A | 918385204 | — | 148,314 shares | $5,584,022 |
| Wave Life Sciences Ltd. | SHS | Y95308105 | — | 822,638 shares | $4,779,527 |
| Protara Therapeutics, Inc. | COM STK | 74365U107 | — | 971,614 shares | $3,711,565 |
| TScan Therapeutics, Inc. | COM | 89854M101 | — | 2,784,792 shares | $2,729,375 |
| Immunome, Inc. | COM | 45257U108 | — | 55,306 shares | $1,171,934 |
| Skye Bioscience, Inc. | COM | 83086J200 | — | 1,575,243 shares | $1,092,116 |
| Sana Biotechnology, Inc. | COM | 799566104 | — | 310,483 shares | $1,083,586 |
| Aligos Therapeutics, Inc. | COM | 01626L204 | — | 83,055 shares | $479,227 |
| Tyra Biosciences, Inc. | COM | 90240B106 | — | 10,607 shares | $338,788 |
| Surrozen, Inc. Warrants @ $172.50 8/11/2026 (15 FOR 1) | W EXP 8/11/2026 | 86889P117 | — | 833,333 shares | $13,750 |