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PERCEPTIVE ADVISORS LLC
Period ended Jun 30, 2026 · Latest filing Aug 14, 2026
These quarterly holdings are delayed and may not include all assets or short positions.
Values are from the reporting date, not current prices or purchase costs.
The same security may appear in multiple rows.
Source: SEC
Reported portfolio value
Quarter-end reported holdings; not current value or investment performance.
View reported values
- Jun 30, 2026: $6,661,817,069
More quarters will appear as history becomes available.
Top holdings
Top 10 at Jun 30, 2026. Matching entries are combined; security classes and options remain separate. Shares exclude principal amounts; option shares reflect the reported underlying amount.
View top holdings values
- PRAXIS PRECISION MEDICINES I · COM NEW · 74006W207 · shares: $681,627,753
- SPYRE THERAPEUTICS INC · COM NEW · 00773J202 · shares: $383,484,855
- CELCUITY INC · COM · 15102K100 · shares: $334,491,064
- ASCENDIS PHARMA A/S · ORD SHS · K08588103 · shares: $310,387,665
- RHYTHM PHARMACEUTICALS INC · COM · 76243J105 · shares: $287,156,334
- ROIVANT SCIENCES LTD · SHS · G76279101 · shares: $286,144,465
- RELAY THERAPEUTICS INC · COM · 75943R102 · shares: $263,926,759
- TRAVERE THERAPEUTICS INC · COM · 89422G107 · shares: $213,183,729
- KARDIGAN INC · COM · 485925101 · shares: $195,585,788
- NUVALENT INC · COM · 670703107 · shares: $195,192,368
Reported holdings
109 reported entries| Issuer | Class | CUSIP | Type | Shares / principal | Reported value (USD) |
|---|---|---|---|---|---|
| PRAXIS PRECISION MEDICINES I | COM NEW | 74006W207 | — | 2,035,986 shares | $681,627,753 |
| SPYRE THERAPEUTICS INC | COM NEW | 00773J202 | — | 4,319,496 shares | $383,484,855 |
| CELCUITY INC | COM | 15102K100 | — | 3,197,200 shares | $334,491,064 |
| ASCENDIS PHARMA A/S | ORD SHS | K08588103 | — | 1,163,721 shares | $310,387,665 |
| RHYTHM PHARMACEUTICALS INC | COM | 76243J105 | — | 2,586,295 shares | $287,156,334 |
| ROIVANT SCIENCES LTD | SHS | G76279101 | — | 8,085,461 shares | $286,144,465 |
| RELAY THERAPEUTICS INC | COM | 75943R102 | — | 14,106,187 shares | $263,926,759 |
| TRAVERE THERAPEUTICS INC | COM | 89422G107 | — | 3,752,574 shares | $213,183,729 |
| KARDIGAN INC | COM | 485925101 | — | 8,200,662 shares | $195,585,788 |
| NUVALENT INC | COM | 670703107 | — | 1,580,505 shares | $195,192,368 |
| EDGEWISE THERAPEUTICS INC | COM | 28036F105 | — | 4,373,974 shares | $177,714,564 |
| APOGEE THERAPEUTICS INC | COM | 03770N101 | — | 1,308,113 shares | $173,625,838 |
| AMYLYX PHARMACEUTICALS INC | COM | 03237H101 | — | 8,334,882 shares | $149,694,481 |
| MEIRAGTX HLDGS PLC | COM | G59665102 | — | 10,786,658 shares | $145,727,749 |
| ORUKA THERAPEUTICS INC | COM | 687604108 | — | 1,345,063 shares | $128,009,646 |
| INHIBRX BIOSCIENCES INC | COM | 45720N103 | — | 1,297,763 shares | $122,963,044 |
| PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | — | 981,879 shares | $120,358,728 |
| SOLID BIOSCIENCES INC | COM NEW | 83422E204 | — | 11,906,646 shares | $118,947,393 |
| ZYMEWORKS INC | COM | 98985Y108 | — | 4,182,953 shares | $109,342,391 |
| TANGO THERAPEUTICS INC | COM | 87583X109 | — | 3,377,000 shares | $105,565,020 |
| IMMATICS N.V | SHS | N44445109 | — | 10,383,456 shares | $105,184,409 |
| NURIX THERAPEUTICS INC | COM | 67080M103 | — | 4,320,422 shares | $104,813,438 |
| BIOCRYST PHARMACEUTICALS INC | COM | 09058V103 | — | 10,308,888 shares | $103,088,880 |
| REVOLUTION MEDICINES INC | COM | 76155X100 | — | 527,600 shares | $98,808,928 |
| AVALYN PHARMACEUTICALS INC | COM SHS | 05348Y105 | — | 2,675,296 shares | $88,070,744 |
| MODERNA INC | COM | 60770K107 | PUT | 1,000,000 shares | $70,030,000 |
| DYNE THERAPEUTICS INC | COM | 26818M108 | — | 2,689,235 shares | $59,727,909 |
| BIOGEN INC | COM | 09062X103 | — | 276,173 shares | $59,669,938 |
| IMMUNOVANT INC | COM | 45258J102 | — | 1,357,383 shares | $52,299,967 |
| UNITEDHEALTH GROUP INC | COM | 91324P102 | — | 116,806 shares | $48,548,078 |
| SPDR SERIES TRUST | ST STR SP BIOT | 78464A870 | PUT | 300,000 shares | $47,475,000 |
| IONIS PHARMACEUTICALS INC | COM | 462222100 | — | 566,000 shares | $44,878,140 |
| SUTRO BIOPHARMA INC | COM SHS | 869367201 | — | 1,304,846 shares | $43,320,887 |
| ALTO NEUROSCIENCE INC | COM SHS | 02157Q109 | — | 1,609,893 shares | $42,485,076 |
| JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 | — | 170,000 shares | $40,964,900 |
| CORVUS PHARMACEUTICALS INC | COM | 221015100 | — | 2,667,441 shares | $39,851,569 |
| SIONNA THERAPEUTICS INC | COM | 829401108 | — | 905,000 shares | $39,810,950 |
| CYTOMX THERAPEUTICS INC. | COM | 23284F105 | — | 10,439,185 shares | $39,146,944 |
| ARTIVION INC | COM | 228903100 | — | 1,737,290 shares | $39,036,906 |
| X4 PHARMACEUTICALS INC | COM NEW | 98420X202 | — | 7,933,491 shares | $37,049,403 |
| CORCEPT THERAPEUTICS INC | COM | 218352102 | — | 398,385 shares | $34,639,576 |
| REPLIGEN CORP | COM | 759916109 | — | 248,212 shares | $33,866,045 |
| ANTERIS TECHNOLOGIES GLOBAL | COM | 03675P102 | — | 3,425,476 shares | $33,740,939 |
| RAPPORT THERAPEUTICS INC | COM | 75383L102 | — | 773,342 shares | $32,225,161 |
| DAMORA THERAPEUTICS INC | COM NEW | 36322Q206 | — | 1,223,000 shares | $31,810,230 |
| CHARLES RIV LABS INTL INC | COM | 159864107 | — | 140,000 shares | $31,750,600 |
| AXSOME THERAPEUTICS INC. | COM | 05464T104 | — | 118,450 shares | $28,993,007 |
| EYEPOINT INC | COM NEW | 30233G209 | PUT | 2,000,000 shares | $28,600,000 |
| DBV TECHNOLOGIES S A | SPONSORED ADS | 23306J309 | — | 1,653,350 shares | $27,114,940 |
| IRHYTHM HOLDINGS INC | COM | 450056106 | — | 223,766 shares | $26,616,966 |
| ADAPTIVE BIOTECHNOLOGIES COR | COM | 00650F109 | — | 1,217,325 shares | $26,111,621 |
| SAB BIOTHERAPEUTICS INC | COM NEW | 78397T202 | — | 6,627,501 shares | $25,847,254 |
| DANAHER CORP DEL | COM | 235851102 | — | 130,000 shares | $24,762,400 |
| TENAX THERAPEUTICS INC | COM NEW | 88032L605 | — | 1,700,000 shares | $24,735,000 |
| CAPRICOR THERAPEUTICS INC | COM NEW | 14070B309 | CALL | 1,000,000 shares | $24,080,000 |
| SELLAS LIFE SCIENCES GROUP I | COM NEW | 81642T209 | PUT | 1,500,000 shares | $22,140,000 |
| NAUTILUS BIOTECHNOLOGY INC | COM | 63909J108 | — | 11,634,211 shares | $21,755,974 |
| ORCHESTRA BIOMED HLDGS INC | COM | 68572M106 | — | 5,037,906 shares | $21,738,564 |
| INTUITIVE SURGICAL INC | COM NEW | 46120E602 | — | 51,884 shares | $20,633,229 |
| ADLAI NORTYE LTD | SPONSORED ADS | 00704R109 | — | 1,793,190 shares | $20,621,685 |
| CONTINEUM THERAPEUTICS INC | CL A | 21217B100 | — | 1,255,592 shares | $20,579,153 |
| NUVECTIS PHARMA INC | COM | 67080T108 | — | 1,000,000 shares | $18,390,000 |
| PALISADE BIO INC | COM | 696389402 | — | 8,425,065 shares | $17,608,386 |
| OMADA HEALTH INC | COM | 68170A108 | — | 786,330 shares | $17,259,943 |
| LEONABIO INC | COM | 04746L203 | — | 1,859,322 shares | $17,087,169 |
| EVOLUS INC | COM | 30052C107 | — | 2,459,285 shares | $17,067,438 |
| NEWAMSTERDAM PHARMA COMPANY | ORDINARY SHARES | N62509109 | PUT | 500,000 shares | $16,945,000 |
| INVIVYD INC | COM | 00534A102 | — | 18,490,636 shares | $16,131,231 |
| CELCUITY INC | NOTE 2.750% 8/0 | 15102KAA8 | — | 6,500,000 principal | $14,629,442 |
| MIRUM PHARMACEUTICALS INC | COM | 604749101 | — | 115,391 shares | $13,508,824 |
| SURROZEN INC | COM NEW | 86889P208 | — | 503,985 shares | $13,078,411 |
| BETA BIONICS INC | COM | 08659B102 | — | 832,944 shares | $13,052,232 |
| CAPRICOR THERAPEUTICS INC | COM NEW | 14070B309 | PUT | 500,000 shares | $12,040,000 |
| AXOGEN INC | COM | 05463X106 | — | 247,312 shares | $11,423,341 |
| OSCAR HEALTH INC | CL A | 687793109 | — | 400,000 shares | $11,408,000 |
| OCULIS HOLDING AG | ORDINARY SHARES | H5870P102 | — | 808,827 shares | $11,218,430 |
| SEAPORT THERAPEUTICS INC | COMMON STOCK | 81221K108 | — | 500,000 shares | $10,860,000 |
| VIRIDIAN THERAPEUTICS INC | COM | 92790C104 | — | 581,980 shares | $10,690,973 |
| BOSTON SCIENTIFIC CORP | COM | 101137107 | — | 250,000 shares | $10,670,000 |
| BILLIONTOONE INC | CL A | 090168105 | — | 86,812 shares | $10,415,704 |
| ABIVAX SA | SPONSORED ADS | 00370M103 | — | 74,000 shares | $9,861,240 |
| NATERA INC | COM | 632307104 | — | 34,689 shares | $9,416,329 |
| ENGENE THERAPEUTICS INC | COM | 29286X101 | — | 4,822,169 shares | $8,342,352 |
| RESEARCH ALLIANCE CORP III | ORD SHS CL A | G75226103 | — | 750,000 shares | $8,025,000 |
| AGOMAB THERAPEUTICS NV | SPONSORED ADS | 00860C102 | — | 600,000 shares | $7,788,000 |
| CULLINAN THERAPEUTICS INC | COM | 230031106 | — | 426,478 shares | $7,766,164 |
| UNIQURE NV | SHS | N90064101 | — | 168,000 shares | $7,738,080 |
| MOBIA MED INC | COMMON STOCK | 60705V103 | — | 523,654 shares | $7,016,963 |
| ADAGIO MED HLDGS INC | COM | 00534B100 | — | 9,876,586 shares | $6,439,534 |
| GUARDANT HEALTH INC | COM | 40131M109 | — | 41,327 shares | $6,200,290 |
| PHATHOM PHARMACEUTICALS INC | COM | 71722W107 | — | 532,000 shares | $5,772,200 |
| OUTLOOK THERAPEUTICS INC | COM | 69012T305 | — | 3,139,216 shares | $4,991,353 |
| COGENT BIOSCIENCES INC | COM | 19240Q201 | — | 121,082 shares | $4,685,873 |
| EDESA BIOTECH INC | COM NEW | 27966L306 | — | 563,239 shares | $4,579,133 |
| AVALO THERAPEUTICS INC | COM NEW | 05338F306 | — | 219,813 shares | $4,062,144 |
| TWIST BIOSCIENCE CORP | COM | 90184D100 | — | 36,812 shares | $3,787,219 |
| CRESCENT BIOPHARMA INC. | COM | G2545C104 | — | 206,942 shares | $3,724,956 |
| XERIS BIOPHARMA HOLDINGS INC | COM | 98422E103 | — | 467,013 shares | $3,698,743 |
| OUTSET MED INC | COM NEW | 690145206 | — | 833,333 shares | $3,599,998 |
| BIODESIX INC | COM | 09075X207 | — | 108,694 shares | $2,451,049 |